Why do people get cancer, how it spreads, and how to prevent it? | Sendurai Mani | TEDxProvidence
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- Опубликовано: 26 сен 2024
- After heart disease, cancer remains the second most common cause of death in the US. Only around 5% of cancers are hereditary, and the remaining 95% are sporadic, contributed by environmental factors and lifestyle. Among these cancers, carcinomas account for over 80%, which develop in epithelial cells. Epithelial cells are attached to one another; therefore, when cancer starts in these cells, they are also attached to one another, confined to the local environment, and develop a benign tumor. At some point, when cancer progresses, the cancer cells activate a latent embryonic program known as epithelial-mesenchymal transition, gain stem cell properties, and start to behave like cells in an embryo. These cancer cells with stem cell properties are resistant to most therapies. They move around the body and develop metastasis. Advancements in sequencing, imaging, and precision oncology allow us to characterize these detrimental cells spatially and temporally at a single-cell level to find a cure for cancer. Sendurai A. Mani is a tenured Professor in the Department of Pathology and Laboratory Medicine and Dean’s Endowed Chair for Translational Oncology. He is also the Associate Director for Translational Oncology at Legorreta Cancer Center and Director of the Cancer Stem Cell Center at Brown University. After completing his Ph.D. at the Indian Institute of Science, Bangalore, India, Dr. Mani joined the Weinberg laboratory at the Whitehead Institute/MIT as a postdoctoral fellow. Dr. Mani and his colleagues at MIT demonstrated that the activation of latent embryonic epithelial-mesenchymal transition (EMT) promotes metastasis. In addition, Dr. Mani was the first to show that the activation of EMT provides stem cell properties to cancer cells. This highly cited finding provided insights into the presence of plasticity within the tumor and how cancer cells survive in the circulation and develop metastasis similar to the tissue of origin at the distant site. Dr. Mani received several prestigious awards, including the V-Scholar and American Cancer Society Research Scholar awards and Dean's Endowed Chair for Translational Oncology at Brown University. He is an elected member of the scientific research honor society Sigma Xi and an elected fellow of the American Association for the Advancement of Sciences (AAAS). This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx
I’m a cancer survivor.
I used to be a health care worker.
I got cancer and learned that treatment is VERY lucrative.
When I had chemo it ranged from $500 a bag and upwards. My mastectomy cost $155,000 in 2019.
As long as treatment is so lucrative and there is an entire industry-oncologist, chemotherapy, pharma- it’ll NEVER get CURED.
Sorry to burst the bubble. It’s about $$
100% CORRECT
I've spend more than 15 years in cancer research. Drug discovery. Cellular & molecular detection. No need for chemo. No need for radiation. It's just too much profit to let the cure end this $$$ making machine.
If you are in Britain and you use the NHS you donnt have to worry about the huge medical bills Americans have. Cannt comment about Canada. My family has a history of colon cancer which is sadly increasing in young people under the age of 40. Read a story about a hardworking gp who git diagnosed at age 35 with stage 3 colon cancer. She thought her symptoms were something else as she had a baby was tired and young. Her husband was a consultant gastrointestinal doctor in a english nhs hospital. The saving grace she will be looked after in terms of medical bills.
I am discovering that it is a corrupt mess.
yeah they gangstalk people who try to heal people alternatively sometimes, sick pharmaceutical companies do anything tro money.
one reason that cancer is decreasing may be that less people are going to the clinic to get an official diagnosis, and my experience is that there are many cases where cancer comes and goes without a diagnosis. More people are using lifestyle changes with diet being the primary variable, and they are not getting a diagnosis.
I love how you described the body as a community! This was such a powerful talk, my friend!
Thank you, Tara!
Yes, that's all you got out of it. Community. Rest was palaver.
4:00 Three types of cancer
7:55 Cancer is an age related disease
9:55 Poor diet/habits
13:15 Future looking bright
Cow's milk develops and grows Cancer cells.
Milk is a animal's growth hormone to grow their babies.
It's very high in Casein and categorized as #1 Carcinogen food by the WHO and the rest of the Science community. Gbu and tc, my friend 💚
Cancer is an age related disease, you mean before 20 years, people above 20 are getting cancer nowadays
Colon cancer is increasing in young people. We need to get free colon cancer screening to age 40. Free yearly screening sun cancers starting age 35. A stich in time saves 9. These are much more easily treated when found early. Lobby your reps at state level and national level.
@@helenahanleyprobably due to glyphosate getting everywhere in the food supply. Glyphosate destroys the gut biome which likely leads to colon cancer.
One of the most clear, articulate, positive, powerful speakers i have seen
Thank you!
@@user-pp9ri4zc4t
Cow's milk develops and grows Cancer cells.
Milk is a animal's growth hormone to grow their babies.
It's very high in Casein and categorized as #1 Carcinogen food by the WHO and the rest of the Science community. Gbu and tc, my friend 💚
We love you Providence for giving us this speaker and talk ! More please !
I know two people successfully on immunotherapy for melanoma. Both were given six months and both are fine and one is over three years on, the other about two years one. Absolutely brilliant for them and their families but it was very expensive.
Both must have been in early stages, and both would have been fine without establishment immunotherapy or chemo. Find better doctors.
@@morespinach9832They would have been fine with Melanoma? The most dangerous cancer (apart from pancreatic)? Bob Marley famously refused to have his toe amputated to prevent melanoma spread…and he’s gone now. Anecdotal story but you get the point. Melanoma must be removed or aggressively treated if it’s spread.
This is a very crucial talk for anyone affected ! Keep sharing this everyone !
Brilliant talk , wonderful speaker with a very important thought leading message for the world ! Appreciate the share Mr Mani !
Resentment, mountains of deep anger and inability to speak yor buried emotions causes cancer.. i deeply feel it even though it hasnt been fully proved yet. But i know....my dad held grudges against random.neighbours and ex colleagues from 40 years ago. If he ever had a slight difference of opinion with anyone, he never spoke to him again and had bursts of anger for decades. He died of carcinoma of bile duct in a very bad situation, after all his organs were removed and he was left at 35 kgs.. even on this deathbed, he was angry at his nephew and was cursing him. I feel so constricted even typing this...he gave me a lot of doscomfort and stiff neck from all those painful memories.i wish he has found his peace.
Thanks for sharing this!! Hope you are okay now.
Wow. Thank you for sharing. Your story reminds me of my mom and MIL. They burn bridges like their world is a scorched earth.
They are mid 70s, early 80s. Live with no peace or really any happiness. They are lonely and retired, but stuck at home and angry at everyone. Sadly, the only peace they will find is when they are dead.
Mr you give hope to a generation
Thank you, Mani, for making complex ideas in simple terms for everyone to understand.
Thank you!
Many of us are here for the same reason so therefore, i recommend that you look at the work of Dr Thomas Seyfried and how his Boston university clinic is tackling cancer using a metabolic approach. While cancer continues to be treated as a genetic disease, we will never get on top of it. It also goes without saying that standard of care (chemotherapy and radiation) is going to do us in anyway.
Dr Thomas is the best at cancer he changed my life for the better.
Cow's milk develops and grows Cancer cells.
Milk is a animal's growth hormone to grow their babies.
It's very high in Casein and categorized as #1 Carcinogen food by the WHO and the rest of the Science community. Gbu and tc, my friend 💚
Yes, cancer is a metabolic dysfunction of the mitochondria. Most sense I've heard in 40 years when it killed my Grandpa. Poisoning, burning & amputating the body is so primitive. Let's move on to science. 🙏💙
I checked you out and you have lots of good news , talks etc , amazing work , inspiring
Although the title of your video say "how to prevent it" you did not say how to prevent cancer. What is the point of giving us an overload of medical information, when we cannot even manage to see a doctor these days. What can we as patients do with that information? We need consciencious doctors who seriously care about their patients health.
He told u numb nuts - get early diagnosis to cure it
Jeez it’ll be done way to go before they invent brain cell corrections
Dr. Jason Fung wrote The Cancer Code.
For everyone interested in all the un-answered questions left by this speaker.
he said don't stress, take time to enjoy life. don't smoke, don't drink alcohol, don't eat junk food, stay away from pollution, be respectful of your microbiome. he told what to do and what not to do but you didn't listen.
He said how to prevent cancer around the 10 minute mark were you even listening
Sounds like you are looking for a pill ?
Outstanding talk, Mani. Thank you.
Thank you, John!
Thank you Sir for sharing wonderful information. If we see the causes of cancer and try to get rid of those factors with help from inside family or outside help. And very important point is to be happy and be respectful towards everyone. Always use good words, all the time our cells are getting the signal of love and hate from us. If love is more, for others too then no cancer. This is what I could understand. Harmony in our cells and bacteria will promote healthy body.
❤
Absolutely amazing many thanks for you work and superb presentation
Thank you, @popotv9385!
Research is lucky to have you, I read about you in an article recently too
Please make treatme t for chronic diseases cheaper. Our right to live shouldnt depend on how much money one has. 😢
Cow's milk develops and grows Cancer cells.
Milk is a animal's growth hormone to grow their babies.
It's very high in Casein and categorized as #1 Carcinogen food by the WHO and the rest of the Science community. Gbu and tc, my friend 💚
Deserves more views More people need to know
Thank you!
Excellent presentation sir. I have shared this with many of my network because it’s very informative and helpful.
The Values Compass- I love this , thank you fort sharing, enlightened !
Some incredible information in this one, I don't know how you remembered it all!
Fantastic talk! Congrats!
Thank you!
Thank you Dr Obaz for your excellent care and compassion. You have gone above and beyond in timely communication and response to our questions and concerns. Thank you for caring and helping us believe in the best possible outcome during our very difficult time
You are amazing. So inspiring
Oh My God! Your video is really Enormous Graceful Frame
Important topic and work you, God bless you all in Providence
This is Fascinating
Thank you!
Love the anecdotel storytelling here, one of the best TEDx Talk I've heard of late !
Anedota???
Beautifully delivered, such stage presence Dr Rai.
Excellent,your video just keep getting better & better All my favorites
I just want to name this Videos.."stunning"
No words, only emotions
Wow one of my favorite
Congratulations Senduari Mani !
Your weekend shares are honestly my favorite. I look forward to them
where does he share? insta?
He says more treatment coming in the future but so many still die today. We need cancer prevention strategies. Cause once it’s in your body, it’s a game over
Prevention helps but eventually it'll get us so we need a treatment option too. A better one.
@@jonfreeman9682 agreed but not sure when that will be coming our way 😔
Cancer is a metabolic disease, it’s not genetic. Otto Warburg won the Nobel Prize for this discovery in 1931.
That's not true, I'm a survivor..Stage one.. Surgery/ Radiation.. 99 percent survival I am cancer free bc of early diagnosis..
Stop saying that to people.
@@lorrie5881Don't be so sure and never let your guard down. Who told you ,you are cancer FREE. Once you are Stage 1 and dr. Says it's cleared, that's for NOW only .....wait for few year, eat all those junk food and sugarry stuff and you will have Stage 4 diagnosis. It's just matter of time. I have seen so many including myself .
GREAT STORY TELLING
Please 🙏 also do something for hepatitus B positive patients 🙏
So empowering, thank you
what is empowering for us though? He didnt talk about what WE can do besides sending them more money and volunteering for clinical trials. We don't have power here.
Silence is golden indeed !!!!!!!!!!!!!!!!!!
Why you say silence? I want to know
Appreciate💕 both you and your Shares Thank you
your Snapshots really awesome, i like it, looking forward for you next Snapshots, keep it up!
One of Thee Best!
Thank you for inspiring me to better ❤️😍😍
Shade, gradient, idea, colour fantastic m8
Value led leadership at its finest in this wonderful talk
Thank you for sharing.
absolutely stunning video Wow
Lifestyle and modern day eating habits are the main cause.
Breathtaking
This looks incredible!!! ❤
One Of The Best Talks in Recent Times 🔥🔥
Thank you, @Manishceo!
@@user-pp9ri4zc4t
Sir is it you in the lecture. Nice to see it. Thank you ❤
Very attractive❇
Prevention was never discussed…. Second part available Mr.Mani ???
It’s was discussed. These are just a few: smoking, eating junk food, microbes…
I would add: Eating a proper human diet (keto/carnivore), avoid alcohol, manage stress, and get some sun and fresh air.
Alcohol stress lifestyle
Great stuff Wish The more success to you
Thank you!
@@user-pp9ri4zc4tawesome explanation, Mani!
Thanks lovely Videos!!
Loved it
Thank you!
💯Exceptionally amazing Videos
Looked at your website too Mani, inspirational work you do!
Suggest a debate with Pr. Seyfried.
❤🌹 God bless you 🙏🙏
Woow thanks for Sharing 🙏
Such Amazing
for all people of peace and love
Super talk.....sendurai mani ... by Prasad Madurai
Thank you, Prasad!
Such notification,many playfulness,so wonderful
An Awesome Example of the Beauty that 🌈Nature Creates Just stylish🔝🔝
You are in the list of favorites
Omg wow! That's incredible💓 I appreciate your Videos
Nice one
Thank you!
Excellent talk Mandeep
Your explanation of the difference between DNA and genes 5:10 is amazing.
Well explained, Mani
👍
Thank you, Saravanan!
Not dealing with your unresolved issues can eat you up inside, literally and figuratively. This is the beginnings of cancer.
Anger, fear, envy, hate, grief, resentment, jealousy
Pleasant video
Great pic,Love the view!💗
Wow👌 Awesome!✌💪☝👏👏👏👏 Very different
Superb!
🔥🔥
You are ravishing♥
Wow this is amazing
Cancer is a thief of life.
Cow's milk develops and grows Cancer cells.
Milk is a animal's growth hormone to grow their babies.
It's very high in Casein and categorized as #1 Carcinogen food by the WHO and the rest of the Science community. Gbu and tc, my friend 💚
Energetic
The cure has been around the corner for the last 50 years.
It’ll never happen because treating it is SO lucrative! I’m a cancer survivor.
There's no cure,...with corrupted cells running upto 20K different mutations what do you expect...??,...a single drug can say control max 3 mutations that somehow look similar,..so how about the 19,997 other mutations...??... reason why with chronic disease patient takes medicine for a fecking lifetime...!!
Some people can give up smoking and drinking but how environment something which is the most difficult.
Now people in the Himalayan region are having cancer diagnosis frequently
I learned a lot! Thank you
exceptional😍💞
Oh wow! That's Fabulous💋 I love your Video
Thanks so much for sharing!
you are so Special thank you for this Videos
great ! thanks !
You are a Star👏
It's fascinating not just cool!
My role model ❤
So excited For This Supercool Videos
Very good photo ✨
Very Wonderful ❤️